3-BROMO-4-PYRIDYLBORONIC ACID - Names and Identifiers
3-BROMO-4-PYRIDYLBORONIC ACID - Physico-chemical Properties
Molecular Formula | C5H5BBrNO2
|
Molar Mass | 201.81 |
Density | 1.785g/cm3 |
Boling Point | 350.041°C at 760 mmHg |
Flash Point | 165.499°C |
Vapor Presure | 0mmHg at 25°C |
Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
Refractive Index | 1.602 |
3-BROMO-4-PYRIDYLBORONIC ACID - Introduction
(3-bromopyridin-4-yl)boronic acid is an organic compound with the chemical formula C5H5BBrNO2. Its appearance was a white crystalline solid. The following is a detailed description of its nature, use, formulation and safety information:
Nature:
(3-bromopyridin-4-yl)boronic acid has a melting point of 195-200 degrees Celsius and a specific gravity of 1.63 g/cm. It is insoluble in water, but can be dissolved in some organic solvents such as dimethyl sulfoxide and alcohol. It can be obtained by a borate exchange reaction catalyzed by cupric chloride in an organic solvent.
Use:
(3-bromopyridin-4-yl)boronic acid is an important organic synthesis intermediate. It can participate as a ligand in metal organic chemical reactions and is used in organic synthesis such as C- C bond formation and aromatic substitution reactions. In addition, it can also be used in drug development, pesticide synthesis and natural product synthesis.
Preparation Method:
(3-bromopyridin-4-yl)boronic acid can be prepared by the following steps: first, pyridine and bromine are reacted in the presence of a catalyst to obtain 3-bromopyridine; then, 3-bromopyridine is reacted with boric acid Under alkaline conditions, the target product can be obtained.
Safety Information:
Limited safety data on (3-bromopyridin-4-yl)boronic acid. However, as an organic compound, it may have some health effects. Appropriate protective measures, including wearing protective gloves and glasses, should be taken during handling and use to ensure well-ventilated laboratory conditions. Avoid contact with skin, eyes, and respiratory tract, and store and handle the compound properly. If necessary, consult professional bodies or relevant safety materials for further information.
Last Update:2024-04-09 21:54:55